For more than half a century this company has been developing drugs used in the treatment of severe pain. It specialises in extended-release drugs, and says it produced the first prolonged-release morphine-sulphate tablets for cancer pain. The business has now begun branching out into medication for respiratory ailments and cardiovascular diseases. Increased sales and a reduction in R&D expenditure helped profits at this Cambridge company rise to £64.7m in 2012, under managing director Dietmar Lietner, 47.
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